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R(+)-Methylindazone
8H-imidazo[4
PDGFR and MAPK signaling pathways as compared to the parent compound
a derivative of fused bicyclic pyrimidine
EC50 = 280 nmol/L)
KT5823 - CAS# 126643-37-6 Catalog No.:M11738-10 R(+)-MethylindazoneKT5823, a selective the cGMP dependent protein kinase (PKG) inhibitor with an Ki value of 0. 23 M, it also inhibits PKA and PKC with Ki values of 10 M and 4 M, respectively. KT5823 is a staurosporine related protein kinase inhibitor, increases thyroid stimulating hormone induced (Na+ I symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0 G1 boundary and causes increases in the levels of apoptotic DNA
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